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Cranberex® - Cranberry Extract

Cranberex®: The Power of Oregon Cranberry

  • Pure whole berry Oregon Cranberry extract (200:1)
  • Comparative testing shows 10 – 15 times more active constituents than leading raw material brands*
  • Test results from Rutgers University show exceptional anti-adhesion activity, as compared to other brands*
  • Levels of ‘A-Type’ PAC’s in Cranberex™ correspond to most effective clinical trials of Cranberry extracts with a dose of 240mg – 480mg. [3]

Cranberex® cranberry extract is a concentrated (200:1), standardized extract that delivers Cranberry’s most active constituents: the unique A-type proanthocyanidins that don’t occur in PAC’s from other tannin-rich foods. [1]

Cranberex® cranberry extract contains 15% A-type PAC’s, as assayed by BL-DMAC, the method now endorsed by USDA, The Cranberry Institute and Rutgers University). [2]

It is this high concentration of A-Type PAC’s that connects Cranberex® to the latest clinical trials that demonstrate the ability of cranberry PAC’s to support urinary tract health.

Cranberex® is a concentrated (200:1), standardized extract that delivers Cranberry’s most active constituents: the unique A-type proanthocyanidins that don’t occur in PAC’s from other tannin-rich foods. [1]

Cranberex® contains 15% A-type PAC’s, as assayed by BL-DMAC, the method now endorsed by USDA, The Cranberry Institute and Rutgers University). [2]

Now available as powder, or encapsulated and bottled to your own formula.

 

The Clinical Studies and Science Behind Cranberex™

1 - In-Vitro Anti-Adhesion Activity (AAA) data from Rutgers University*

This in-vitro study compared the AAA of Cranberex® with nine other brands of cranberry extract (raw material and finished products). In this study, Cranberex™ met the anti-adhesion criteria at a concentration of only 0.23mg/mL. The next most potent brand required a concentration of 60mg/mL to achieve the same anti-adhesion result. The study concluded that Cranberex™ had excellent anti-adhesion activity.

2 - Ex-Vivo AAA study from Rutgers University*

This study, was designed to test AAA activity in the urine after consumption of standard dosage of Cranberex.® The study found that AAA response increased rapidly in all participants 3 – 6 hours after consumption of Cranberex®. Half of the participants achieved 100% or significant bacterial Anti-Adhesion Activity, while half achieved 50%, resulting in an average of 75% AAA. (see fig 2).

3 – Cranberex™ dosage level

The recent, multicentric randomized, double blind clinical trial clearly affirmed a bacterial anti-adhesion effect in urine, based upon 36mg/day of cranberry PAC (by BL-DMAC method) [3]. It also reported that effectiveness was dose-dependent, prolonged up to 24 hours with 72 mg of PAC, and increasing with the amount of PAC (by BL-DMAC method) consumed.

4 – Comparative potency testing

Tests that compared PAC levels in Cranberex™ with five leading finished product brands, showed a far greater potency in Cranberex™ (see fig 1).

* Copies of these tests and studies are available upon request

Fig. 1 – mg of PAC’s per cap/tab of leading cranberry extracts Fig. 2 – Average AAA activity of 10 subjects

Source: Rutgers University, Feb 2007, Bacterial Anti-adhesion Activity of Human Urine: Cranberex (Ethical Naturals)

5. The Need for Premium Clinically Tested Cranberry Extracts

UTI’s are one of the most common bacterial infections accounting for 10.5 million visits to doctor’s offices each year, and costing an estimated $3.5 billion per year in the US alone [6]. Some estimates place the percentage of antibiotic resistant cases at up to 10% of this number. As a result, many people are looking for alternative, naturally based ways to support UT Health. The science behind Cranberex® makes it ideal for those seeking health based solutions.

Encapsulated and Bottled Finished Products:
Save your time and money through our in-house manufacturing services, certified to FDA 21 CFR-111 and FSMA compliance by NSF

Through our vertically integrated supply chain, testing lab and manufacturing facility ENI can provide you with the ultimate in convenience and confidence for your branded Cranberex® stand alone, and special formulas. This vertical integration also allows us to offer an integrated cost advantage directly to your company, along with the confidence of fully certified manufacturing.

From field to finished product®

The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or mitigate and disease.


References:
[1] Howell, A.B., et al. (2005). A-type cranberry proanthocyanidins and uropathogenic bacterial anti-adhesion activity. Phytochemistry 66, 2281–2291.
[2] Prior, R. L. et al. (2009). Multi-laboratory validation of a standard method for quantifying proanthocyanidins in cranberry powders. (www.interscience.wiley.com) DOI 10.1002/jsfa.3966.
[3] Kaspar, K. L., et al (2015). A randomized, double-blind, placebo-controlled trial to assess the bacterial anti-adhesion effects of cranberry extract beverages. Food Funct 6 (4):1212-7.
[4] Howell, A. B. et al (2010). Dosage effect on uropathogenic Escherichia coli anti-adhesion activity in urine following consumption of cranberry powder standardized for proanthocyanidin content: a multicentric randomized double blind study. BMC Infectious Diseases. Retrieved on 7/11/2016 from ncbi.nlm.nih.gov
[5] American Herbal Pharmacopoeia and Therapeutic Compendium (2016). Cranberry Fruit, Vaccinium macrocarpon Aiton, Revision. Page 15.
[6] Flores-Mireles, A,L., et al. Urinary tract infections: epidemiology, mechanisms of infection and treatment options. Nat Rev Microbiology 2015 May. 13(5) 269-284

Ethical Naturals, Inc. manufactures the highest-grade nutritional supplement products, at exceptional prices. NSF-111 certified manufacturing, highest GMP.

 
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