VinCare® Patented, GRAS affirmed whole grape extract, standardized for polyphenol and anti-oxidant levels

VinCare® is a patented, GRAS affirmed, whole grape extract, standardized to contain a minimum of 80% polyphenols, with an anti-oxidant level rated to 15,000 μmol TE/gram. These precise standards are maintained by a US patented manufacturing process, and guaranteed through ENI’s NSF certified laboratory testing and distribution facility.

VinCare® cardiovascular benefits supported by clinical trial

A double-blind, placebo controlled clinical study, performed by KGK Laboratories and published in the Journal of Functional Foods[1], showed significant benefits in levels of HDL-cholesterol, compared to placebo. Also that the VinCare® group experienced improvements in the ratio of total cholesterol to HDL cholesterol, reported to be the most specific lipid risk factor for cardiovascular disease (CVD).

The researchers reported that: “These results are of clinical significance in this population of subjects as the role of HDL-C in reverse cholesterol transport is well documented,” wrote the researchers, “and is believed to be cardioprotective, with each 1 mg/dL increase in HDL-C being associated with a 2–4% reduction in the risk of coronary heart disease."

“It is also known that raising HDL-C concentration reduces cardiovascular disease risk independent of LDL-C lowering.”

VinCare® clinical study supports Structure/Function claims

The study now supports specific S/F claims for Vincare® relating to healthy cholesterol levels and cardiovascular health. These claims conform to FDA and FTC guidelines for the category. The claims include:

  • Vincare® supports healthy cholesterol levels and cardiovascular health.
  • In healthy individuals there is a proper balance between HDL ‘good’ cholesterol and LDL ‘bad’ cholesterol. Taken as directed, Vincare® helps maintain healthy cholesterol levels, and supports cardiovascular health

Grape extracts and focus on polyphenols

The benefits of grape polyphenols are a growing focus of clinical studies, and this is reflected in their increasing use as supplement ingredients. Recent studies have shown health support benefits in a number of areas, including: cardiovascular and cholesterol health [1], blood pressure regulation [2], gut microbiota [3], neuroprotection [4], diabetes [5], and overall anti-oxidant ability [1].

Though Vincare® is ENI’s key grape extract product, the company has specialized in the development of grape polyphenol based extracts from the whole fruit, skin and seed, and have a wide experience in using these extracts to enhance other nutritional formulas. For example, grape polyphenols are an ideal co-factor to use with vitamin-C, and this is a key ingredient in ENI’s Polyphenol-C™ vitamin C blend (that also includes other berry polyphenols). Resveratrol is also an ingredient in red grapes, and ENI has developed an extract standardized to grape sourced resveratrol.


[1] Evans, M., et al. (2014). A randomized, double-blind, placebo-controlled, pilot study to evaluate The effect of whole grape extract on antioxidant status, Journal of Functional Foods
[2] Tjelle, T.E., et al. (2015) Polyphenol-rich juices reduce blood pressure measures in a randomized controlled trial in high normal and hypertensive volunteers. British Journal of Nutrition.
[3] Nash, V., et al. (2018) The effect of grape and red wine polyphenols on gut microbiota – A systematic review. Food Research International, Vol 113, Nov 2018.
[4] Zhao, D. et al. A critical review on grape polyphenols for neuroprotection: strategies to enhance bioefficacy. Critical Reviews in Food Science and Nutrition. Vol 60, 2020 – Issue 4
[5] Feeney, M.J. (2004). Fruits and the prevention of lifestyle-related disease. Clinical and Experimental Pharmacology and Physiology, 31 (s2), S11–S13.


VinCare® is now available in powder, or manufactured into vegetable capsules. Please contact us for complete specifications.


Whole Grape Extract Manufacturer VinCare®

Ethical Naturals Inc., is certified to comply with NSF GMP Registration Program Requirements of NSF/ANSI 173, Section 8 which includes FSMA and cGMP (21 CFR 111), (21 CFR 117).

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