VinCare® Patented, GRAS affirmed whole grape extract, standardized for polyphenol and anti-oxidant levels
VinCare® is a patented, GRAS affirmed, whole grape extract, standardized to contain a minimum of 80% polyphenols, with an anti-oxidant level rated to 15,000 μmol TE/gram. These precise standards are maintained by a US patented manufacturing process, and guaranteed through ENI’s NSF certified laboratory testing and distribution facility.
VinCare® cardiovascular benefits supported by clinical trial
A double-blind, placebo controlled clinical study, performed by KGK Laboratories and published in the Journal of Functional Foods, showed significant benefits in levels of HDL-cholesterol, compared to placebo. Also that the VinCare® group experienced improvements in the ratio of total cholesterol to HDL cholesterol, reported to be the most specific lipid risk factor for cardiovascular disease (CVD).
The researchers reported that: “These results are of clinical significance in this population of subjects as the role of HDL-C in reverse cholesterol transport is well documented,” wrote the researchers, “and is believed to be cardioprotective, with each 1 mg/dL increase in HDL-C being associated with a 2–4% reduction in the risk of coronary heart disease."
“It is also known that raising HDL-C concentration reduces cardiovascular disease risk independent of LDL-C lowering.”
VinCare® clinical study supports Structure/Function claims
The study now supports specific S/F claims for Vincare® relating to healthy cholesterol levels and cardiovascular health. These claims conform to FDA and FTC guidelines for the category. The claims include:
- Vincare® supports healthy cholesterol levels and cardiovascular health.
- In healthy individuals there is a proper balance between HDL ‘good’ cholesterol and LDL ‘bad’ cholesterol. Taken as directed, Vincare® helps maintain healthy cholesterol levels, and supports cardiovascular health
Grape extracts and focus on polyphenols
The benefits of grape polyphenols are a growing focus of clinical studies, and this is reflected in their increasing use as supplement ingredients. Recent studies have shown health support benefits in a number of areas, including: cardiovascular and cholesterol health , blood pressure regulation , gut microbiota , neuroprotection , diabetes , and overall anti-oxidant ability .
Though Vincare® is ENI’s key grape extract product, the company has specialized in the development of grape polyphenol based extracts from the whole fruit, skin and seed, and have a wide experience in using these extracts to enhance other nutritional formulas. For example, grape polyphenols are an ideal co-factor to use with vitamin-C, and this is a key ingredient in ENI’s Polyphenol-C™ vitamin C blend (that also includes other berry polyphenols). Resveratrol is also an ingredient in red grapes, and ENI has developed an extract standardized to grape sourced resveratrol.
 Evans, M., et al. (2014). A randomized, double-blind, placebo-controlled, pilot study to evaluate The effect of whole grape extract on antioxidant status, Journal of Functional Foods
 Tjelle, T.E., et al. (2015) Polyphenol-rich juices reduce blood pressure measures in a randomized controlled trial in high normal and hypertensive volunteers. British Journal of Nutrition.
 Nash, V., et al. (2018) The effect of grape and red wine polyphenols on gut microbiota – A systematic review. Food Research International, Vol 113, Nov 2018.
 Zhao, D. et al. A critical review on grape polyphenols for neuroprotection: strategies to enhance bioefficacy. Critical Reviews in Food Science and Nutrition. Vol 60, 2020 – Issue 4
 Feeney, M.J. (2004). Fruits and the prevention of lifestyle-related disease. Clinical and Experimental Pharmacology and Physiology, 31 (s2), S11–S13.
VinCare® is now available in powder, or manufactured into vegetable capsules. Please contact us for complete specifications.